Introduction As a vital mechanism of survival, lymphopoiesis requires the collaboration of
different signaling molecules to orchestrate each step of cell development and maturation …

Leukemias are hematological neoplasms characterized by dysregulations in several cellular
signaling pathways, prominently including the PI3K/AKT/mTOR pathway. Since this pathway …

Background: The intertwining between cancer pathogenesis and aberrant expression of
either oncogenes or tumor suppressor proteins ushered the cancer therapeutic approaches …

Backgrounds Although ATO is widely used to treat acute promelocytic leukemia (APL), the
appropriate effects of the drug as a single agent are achieved in high doses which are not …

The emergence of the drugs targeting epigenetic alterations has brought an optimistic
outlook for cancer patients and probably put an end into the devastating effects of the …

The success in the identification of BCR/ABL tyrosine kinase role in the pathogenesis of
chronic myeloid leukemia (CML) went as far as to find a path to cure this leukemia; however …

The strong storyline behind the critical role of cyclin-dependent kinase (CDK) inhibitor
proteins in natural defense against malignant transformation not only represents a heroic …

Due to the frequent contribution in the pathogenesis of different human malignancies, c-Myc
is among those transcription factors that are believed to be pharmacologically targeted for …

Although the identification of tyrosine kinase inhibitors (TKIs) has changed the treatment
paradigm of many cancer types including chronic myeloid leukemia (CML), still adjustment …

By the creation of nanoscale-materials, nanotechnology has emerged as one of the focal
points of modern medical investigations and nanotechnology-based cancer treatment …