Cancer immunotherapy has become an attractive approach of cancer treatment with
tremendous success in treating various advanced malignancies. The development and …

One of the hallmarks of cancer cells is their ability to evade cell death via apoptosis. The
inhibitor of apoptosis proteins (IAPs) are a family of proteins that act to promote cell survival …

The cellular inhibitors of apoptosis (cIAP) 1 and 2 are amplified in about 3% of cancers and
have been identified in multiple malignancies as being potential therapeutic targets as a …

Inhibitor of apoptosis proteins (IAPs) are suggested as therapeutic targets for cancer
treatment. Smac/DIABLO is a natural IAP antagonist in cells; therefore, Smac mimetics have …

Background Current therapies fail to cure over a third of osteosarcoma patients and around
three quarters of those with metastatic disease.“Smac mimetics”(also known as “IAP …

Osteosarcoma is the most common primary bone malignancy in teenagers and continues to
confer a generally poor prognosis due to its highly metastatic potential. Poor solubility in …

Osteosarcoma is the most common form of primary bone cancer. Over 20% of osteosarcoma
patients present with pulmonary metastases at diagnosis, and nearly 70% of these patients …

Abstract Purpose of Review Osteosarcoma (OS) is the most common cancer of bone, yet is
classified as a rare cancer. Treatment and outcomes for OS have not substantively changed …

Osteosarcoma, a common malignancy in large dog breeds, typically metastasises from long
bones to lungs and is usually fatal within 1 to 2 years of diagnosis. Better therapies are …

Apoptosis resistance remains a major obstacle to treatment failure in sarcoma. Necroptosis
is a caspase-independent programmed cell death, investigated as a novel strategy to …