Abstract Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a
crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Simple Summary The RAS/RAF/MEK/ERK pathway is implicated in fundamental processes
frequently altered in tumors, such as cell proliferation and survival. In breast cancer, it is …

Background Breast cancer is a complex disease with a highly immunosuppressive tumor
microenvironment, and has limited clinical response to immune checkpoint blockade (ICB) …

Inhibitors of fibroblast growth factor receptor (FGFR) signaling have been investigated in
various human cancer diseases. Recently, the first compounds received FDA approval in …

Context Bladder cancer (BLCA) is a highly prevalent tumour and a health problem
worldwide, especially among men. Recent work has highlighted the relevance of the tumour …

As our grasp of cancer genomics deepens, we are steadily progressing towards the domain
of precision medicine, where targeted therapy stands out as a revolutionary breakthrough in …

Cancer has been described as the wound that does not heal, in large part due to fibroblast
involvement. Activation of cancer-associated fibroblasts (CAFs) contributes to critical …

Triple-negative breast cancer (TNBC) is the most aggressive subtype and has a poor
response to treatment due to an immunosuppressive microenvironment. Chinese Medicine …

To overcome the oxidative stress and resistance of cancer stem cells (CSCs) for successful
metastatic triple-negative breast cancer (TNBC) treatment, we report polyhedral …