Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Multidrug resistance (MDR) is a significant issue associated with the clinical application of
antibiotics. It is also challenging to discover and develop new antibiotics with novel …

In recent years, gold compounds have gained more and more attentions in the design of
new metal anticancer drugs. Numerous researches have reported that gold compounds, in …

There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin
reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has …

The development of novel materials is necessary for adequate delivery of drugs to combat
the Methicillin-resistant Staphylococcus aureus (MRSA) burden due to the limitations of …

Owing to the growing hardware capabilities and the enhancing efficacy of computational
methodologies, computational chemistry approaches have constantly become more …

Vancomycin-resistant enterococci (VRE) are a serious public health threat and a leading
cause of healthcare-associated infections. Bacterial resistance to antibiotics recommended …

Vancomycin-resistant enterococci (VRE) represent a major public health threat that requires
the development of new therapeutics. In the present study, acetazolamide (AZM) was …

Neisseria gonorrhoeae represents an urgent public health threat due to the rapid
emergence of resistance to current antibiotics and the limited number of anti-gonococcal …

Objectives The rapid emergence of hypervirulent Clostridium difficile (C. difficile) isolates
and the paucity of effective anti-clostridial antibiotics call for extensive research to identify …