Approximately, one in three ischemic stroke survivors suffered from depression, namely,
post-stroke depression (PSD). PSD affects functional rehabilitation and may lead to poor …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Background Post-stroke depression (PSD) is a common mental disorder of stroke survivors,
its pathogenesis remains elusive. Previous studies suggested a role of the microbiota-gut …

Post-stroke depression (PSD) affects approximately one-third of stroke survivors, severely
impacting general recovery and quality of life. Despite extensive studies, the exact …

Recent studies provide evidence that similar to early-stage Parkinson's disease, depression
is a neurodegenerative disease characterized by the degeneration of monoamine axons …

Background Post-stroke depression (PSD) is one of the most common neuropsychiatric
complications after stroke. However, the underlying mechanisms of PSD remain ambiguous …

Stroke is a highly prevalent and widely detrimental cardiovascular disease, frequently
resulting in impairments of both motor function and neural psychological capabilities, such …

The pathology of depression is related to the imbalance of various neurotransmitters. The
dorsal raphe nucleus (DRN), the main brain region producing 5-HT, is crucially involved in …

Selective serotonin (5-HT) reuptake inhibitors are only 30% effective for remission in
subjects with major depression, and the best treatments for SSRI-resistant patients remain …

Poststroke depression (PSD) does not exist before and occurs after the stroke. PSD can
appear shortly after the onset of stroke or be observed in the weeks and months after the …