Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Netrins are secreted proteins that were first identified as guidance cues, directing cell and
axon migration during neural development. Subsequent findings have demonstrated that …

Urate, a naturally occurring product of purine metabolism, is a scavenger of biological
oxidants implicated in numerous disease processes,,, as demonstrated by its capacity of …

Calcium-triggered fusion of synaptic vesicles and neurotransmitter release are fundamental
signalling steps in the central nervous system. It is generally assumed that fast transmitter …

Growth cones contain mRNAs, translation machinery, and, as we report here, protein
degradation machinery. We show that isolated retinal growth cones immediately lose their …

Biomolecule gradients have been shown to play roles in a wide range of biological
processes including development, inflammation, wound healing, and cancer metastasis …

Netrin-1 is an evolutionarily conserved, secreted extracellular matrix protein involved in
axon guidance at the central nervous system midline,. Netrin-1 is expressed by cells …

Developing axons are guided to their targets by attractive and repulsive guidance cues. In
the embryonic spinal cord, the floor plate chemoattractant Netrin-1 is required to guide …

Netrin1 has been proposed to act from the floor plate (FP) as a long-range diffusible
chemoattractant for commissural axons in the embryonic spinal cord. However, netrin1 …

Far-red light regulates many aspects of seedling development, such as inhibition of
hypocotyl elongation and the promotion of greening, acting in part through phytochrome A …