Despite tremendous advances in the field of regenerative medicine, it still remains
challenging to repair the osteochondral interface and full-thickness articular cartilage …

One of the most important issues facing cartilage tissue engineering is the inability to move
technologies into the clinic. Despite the multitude of current research in the field, it is known …

Articular cartilage was predicted to be one of the first tissues to successfully be regenerated,
but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has …

Background: The surfaces of the bones in the knee are covered with articular cartilage, a
rubber-like substance that is very smooth, allowing frictionless movement in the joint and …

Background: Characterized chondrocyte implantation (CCI) results in significantly better
early structural tissue regeneration than microfracture (MF), and CCI has a midterm clinical …

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a
highly organized extracellular matrix comprising collagen II fibrils, proteoglycans …

OBJECTIVE: To determine and compare failure, re-operation, and complication rates of all
generations and techniques of autologous chondrocyte implantation (ACI). METHODS: A …

Cartilage injury originating from trauma or osteoarthritis is a common joint disease that can
bring about an increasing social and economic burden in modern society. On account of its …

Articular cartilage defects heal poorly. Autologous Matrix-Induced Chondrogenesis (AMIC) is
an innovative treatment for localized full-thickness cartilage defects combining the well …

Background Autologous chondrocyte implantation (ACI) is frequently used to treat
symptomatic defects of the articular cartilage. Purpose To test whether matrix-associated …