Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …

The C9ORF72-linked diseases amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) are characterized by the nuclear depletion and cytoplasmic accumulation of …

TDP-43 is an aggregation-prone protein which accumulates in the hallmark pathological
inclusions of amyotrophic lateral sclerosis (ALS). However, the analysis of deeply …

Loss of function (LoF) of TAR-DNA binding protein 43 (TDP-43) and mis-localization,
together with TDP-43-positive and hyperphosphorylated inclusions, are found in post …

Frontotemporal dementia (FTD) is one of the most common neurodegenerative diseases,
encompassing a myriad of different, clinically distinct subtypes which all target the …

TAR DNA binding protein of 43 kDa (TDP-43)-positive inclusions in neurons are a hallmark
of several neurodegenerative diseases including familial amyotrophic lateral sclerosis …

In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-
43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in …

The risk of Alzheimer's disease (AD) has a strong genetic component, also in the case of late-
onset AD (LOAD). Attempts to sequence whole genome in large populations of subjects …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by
nuclear depletion and cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43) …

Introduction Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly
understood pathophysiology. Recent studies have highlighted systemic inflammation …