Cannabinoids and the expanded endocannabinoid system in neurological disorders

L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Cannabinoids as anticancer drugs: current status of preclinical research

B Hinz, R Ramer - British journal of cancer, 2022 - nature.com
Drugs that target the endocannabinoid system are of interest as pharmacological options to
combat cancer and to improve the life quality of cancer patients. From this perspective …

Cannabidiol: State of the art and new challenges for therapeutic applications

S Pisanti, AM Malfitano, E Ciaglia, A Lamberti… - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9-THC and cannabidiol (CBD) are the …

[HTML][HTML] Terpenes in Cannabis sativa–From plant genome to humans

JK Booth, J Bohlmann - Plant Science, 2019 - Elsevier
Cannabis sativa (cannabis) produces a resin that is valued for its psychoactive and
medicinal properties. Despite being the foundation of a multi-billion dollar global industry …

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

[HTML][HTML] Anticancer mechanisms of cannabinoids

G Velasco, C Sánchez, M Guzmán - Current Oncology, 2016 - ncbi.nlm.nih.gov
In addition to the well-known palliative effects of cannabinoids on some cancer-associated
symptoms, a large body of evidence shows that these molecules can decrease tumour …

The endocannabinoid system as an emerging target of pharmacotherapy

P Pacher, S Bátkai, G Kunos - Pharmacological reviews, 2006 - ASPET
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Towards the use of cannabinoids as antitumour agents

G Velasco, C Sánchez, M Guzmán - Nature Reviews Cancer, 2012 - nature.com
Various reports have shown that cannabinoids (the active components of marijuana and
their derivatives) can reduce tumour growth and progression in animal models of cancer, in …

The endocannabinoid system: A target for cancer treatment

C Laezza, C Pagano, G Navarra, O Pastorino… - International journal of …, 2020 - mdpi.com
In recent years, the endocannabinoid system has received great interest as a potential
therapeutic target in numerous pathological conditions. Cannabinoids have shown an …

Programming of neural cells by (endo) cannabinoids: from physiological rules to emerging therapies

M Maccarrone, M Guzmán, K Mackie… - Nature Reviews …, 2014 - nature.com
Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …