Shadow enhancers: Frequently asked questions about distributed cis‐regulatory information and enhancer redundancy
S Barolo - Bioessays, 2012 - Wiley Online Library
This paper, in the form of a frequently asked questions page (FAQ), addresses outstanding
questions about “shadow enhancers”, quasi‐redundant cis‐regulatory elements, and their …
questions about “shadow enhancers”, quasi‐redundant cis‐regulatory elements, and their …
[HTML][HTML] Shadow enhancers are pervasive features of developmental regulatory networks
Embryogenesis is remarkably robust to segregating mutations and environmental variation;
under a range of conditions, embryos of a given species develop into stereotypically …
under a range of conditions, embryos of a given species develop into stereotypically …
Phenotypic robustness conferred by apparently redundant transcriptional enhancers
Genes include cis-regulatory regions that contain transcriptional enhancers. Recent reports
have shown that developmental genes often possess multiple discrete enhancer modules …
have shown that developmental genes often possess multiple discrete enhancer modules …
[HTML][HTML] Shadow enhancers foster robustness of Drosophila gastrulation
Critical developmental control genes sometimes contain" shadow" enhancers that can be
located in remote positions, including the introns of neighboring genes [1]. They nonetheless …
located in remote positions, including the introns of neighboring genes [1]. They nonetheless …
The embryo as a laboratory: quantifying transcription in Drosophila
Transcriptional regulation of gene expression is fundamental to most cellular processes,
including determination of cellular fates. Quantitative studies of transcription in cultured cells …
including determination of cellular fates. Quantitative studies of transcription in cultured cells …
[HTML][HTML] Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness
The regulatory logic of time-and tissue-specific gene expression has mostly been dissected
in the context of the smallest DNA fragments that, when isolated, recapitulate native …
in the context of the smallest DNA fragments that, when isolated, recapitulate native …
[HTML][HTML] Subtle changes in motif positioning cause tissue-specific effects on robustness of an enhancer's activity
Deciphering the specific contribution of individual motifs within cis-regulatory modules
(CRMs) is crucial to understanding how gene expression is regulated and how this process …
(CRMs) is crucial to understanding how gene expression is regulated and how this process …
Redundant and Cryptic Enhancer Activities of the Drosophila yellow Gene
Evolutionary changes in enhancers, which control gene expression, often contribute to
phenotypic evolution. Here, Kalay et al. examine how enhancer activities are encoded within …
phenotypic evolution. Here, Kalay et al. examine how enhancer activities are encoded within …
Molecular antagonism between X-chromosome and autosome signals determines nematode sex
B Farboud, P Nix, MM Jow, JM Gladden… - Genes & …, 2013 - genesdev.cshlp.org
Sex is determined in Caenorhabditis elegans by the ratio of X chromosomes to the sets of
autosomes, the X: A signal. A set of genes called X signal elements (XSEs) communicates X …
autosomes, the X: A signal. A set of genes called X signal elements (XSEs) communicates X …
The role of the epidermis enhancer element in positive and negative transcriptional regulation of ebony in Drosophila melanogaster
N Akiyama, S Sato, KM Tanaka, T Sakai, A Takahashi - G3, 2022 - academic.oup.com
The spatiotemporal regulation of gene expression is essential to ensure robust phenotypic
outcomes. Pigmentation patterns in Drosophila are determined by pigments biosynthesized …
outcomes. Pigmentation patterns in Drosophila are determined by pigments biosynthesized …