Diversity in chemical structures and biological properties of plant alkaloids

S Bhambhani, KR Kondhare, AP Giri - Molecules, 2021 - mdpi.com
Phytochemicals belonging to the group of alkaloids are signature specialized metabolites
endowed with countless biological activities. Plants are armored with these naturally …

Tropane alkaloids: chemistry, pharmacology, biosynthesis and production

KL Kohnen-Johannsen, O Kayser - Molecules, 2019 - mdpi.com
Tropane alkaloids (TA) are valuable secondary plant metabolites which are mostly found in
high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are …

Biosynthesis of medicinal tropane alkaloids in yeast

P Srinivasan, CD Smolke - Nature, 2020 - nature.com
Tropane alkaloids from nightshade plants are neurotransmitter inhibitors that are used for
treating neuromuscular disorders and are classified as essential medicines by the World …

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

F Zhang, F Qiu, J Zeng, Z Xu, Y Tang, T Zhao… - Nature …, 2023 - nature.com
Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …

Alkaloid biosynthesis: metabolism and trafficking

J Ziegler, PJ Facchini - Annu. Rev. Plant Biol., 2008 - annualreviews.org
Alkaloids represent a highly diverse group of compounds that are related only by the
occurrence of a nitrogen atom in a heterocyclic ring. Plants are estimated to produce …

Mining the biodiversity of plants: a revolution in the making

V De Luca, V Salim, SM Atsumi, F Yu - Science, 2012 - science.org
Only a small fraction of the immense diversity of plant metabolism has been explored for the
production of new medicines and other products important to human well-being. The …

Expansion of chemical space for natural products by uncommon P450 reactions

X Zhang, S Li - Natural product reports, 2017 - pubs.rsc.org
Covering: 2000 to 2017 Cytochrome P450 enzymes (P450s) are the most versatile
biocatalysts in nature. The catalytic competence of these extraordinary hemoproteins is …

RNA interference: promising approach to combat plant viruses

S Akbar, Y Wei, MQ Zhang - International Journal of Molecular Sciences, 2022 - mdpi.com
Plant viruses are devastating plant pathogens that severely affect crop yield and quality.
Plants have developed multiple lines of defense systems to combat viral infection. Gene …

The molecular cloning of artemisinic aldehyde Δ11 (13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua

Y Zhang, KH Teoh, DW Reed, L Maes… - Journal of Biological …, 2008 - ASBMB
At some point during biosynthesis of the antimalarial artemisinin in glandular trichomes of
Artemisia annua, the Δ11 (13) double bond originating in amorpha-4, 11-diene is reduced …

Plant cytochrome P450 plasticity and evolution

CC Hansen, DR Nelson, BL Møller, D Werck-Reichhart - Molecular Plant, 2021 - cell.com
The superfamily of cytochrome P450 (CYP) enzymes plays key roles in plant evolution and
metabolic diversification. This review provides a status on the CYP landscape within green …