Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among
patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications …

Cardiac myocytes can undergo programmed cell death in response to a variety of insults
and apoptotic elimination of myocytes from the adult myocardium can lead directly to …

Although oxidative stress causes activation of c-Jun N-terminal kinase (JNK) and apoptosis
in many cell types, how the JNK pathway is connected to the apoptosis pathway is unclear …

Fas is a widely expressed cell surface receptor that can initiate apoptosis when activated by
its ligand (FasL). Whereas Fas abundance on cardiac myocytes increases in response to …

Doxorubicin is an extensively used anti-neoplastic drug used for solid and hematogenous
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …

Diabetes affects cardiac structure and function, and it has been suggested that diabetes
leads to cardiomyopathy. Arachidonate 12/15-lipoxygenase (LOX) has been suggested to …

Apoptosis has been implicated in both acute and chronic heart diseases. The loss of
myocardium is an important pathogenic process in heart and, hence, the inhibition of …

It has been suggested that apoptosis may be responsible for a significant amount of the
cardiomyocyte death that contributes to the development and progression of heart failure …

Apoptosis is a tightly regulated, cell deletion process that plays an important role in various
cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure …

Mitogen-activated protein kinase kinase kinase (MEKK1) mediates activation of c-Jun NH2-
terminal kinase (JNK). Although previous studies using cultured cardiac myocytes have …