The process by which extracellular signals are relayed from the plasma membrane to
specific intracellular sites is an essential facet of cellular regulation. Many signaling …

Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-
dependent protein kinases. Induction of LTP increased the phosphorus-32 labeling of α …

Nerve cells communicate with each other through two mechanisms, referred to as fast and
slow synaptic transmission. Fast-acting neurotransmitters, eg, glutamate (excitatory) and γ …

Although opioids are highly effective for the treatment of pain, they are also known to be
intensely addictive. There has been a massive research investment in the development of …

We have characterized the phosphorylation of the glutamate receptor subunit GluR1, using
biochemical and electrophysiological techniques. GluR1 is phosphorylated on multiple sites …

Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …

Brief bath application of N-methyl-D-aspartate (NMDA) to hippocampal slices produces long-
term synaptic depression (LTD) in CA1 that is (1) sensitive to postnatal age,(2) saturable,(3) …

Ionotropic neurotransmitter receptors mediate rapid synaptic transmission in the CNS and
PNS. Owing to this central role in trans-synaptic signal transduction, modulation of these …

Today, it is widely appreciated that protein–protein interactions play a fundamental role in
biological processes. This was not always the case. The study of protein interactions started …

Modulation of postsynaptic AMPA receptors in the brain by phosphorylation may play a role
in the expression of synaptic plasticity at central excitatory synapses. It is known from …