Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

The brain‐derived neurotrophic factor, BDNF, was discovered more than 30 years ago and,
like other members of the neurotrophin family, this neuropeptide is synthetized as a …

Serotonin is probably best known for its role in conveying a sense of contentedness and
happiness. It is one of the most unique and pharmacologically complex monoamines in both …

It was recently suggested that supplying the brain with new neurons could counteract
Alzheimer's disease (AD). This provocative idea requires further testing in experimental …

The presence of neural stem cells (NSCs) and the production of new neurons in the adult
brain have received great attention from scientists and the public because of implications to …

Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin,
norepinephrine and dopamine, and plays a major role in the onset, progression and therapy …

The GABAergic deficit hypothesis of major depressive disorders (MDDs) posits that reduced
γ-aminobutyric acid (GABA) concentration in brain, impaired function of GABAergic …

Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …

Within the dentate gyrus of the adult hippocampus is the subgranular zone, which contains a
neurogenic niche for radial-glia like cells, the most primitive neural stem cells in the adult …

Antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs) specifically
increase serotonin (5-HT) levels in the synaptic cleft and are widely used to treat mood and …