Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process optimization

E Trenkenschuh, W Friess - European journal of pharmaceutics and …, 2021 - Elsevier
Lyophilization of nanoparticle (NP) suspensions is a promising technology to improve
stability, especially during long-term storage, and offers new routes of administration in solid …

Polymer-based nanocapsules for drug delivery

CE Mora-Huertas, H Fessi, A Elaissari - International journal of …, 2010 - Elsevier
A review of the state of knowledge on nanocapsules prepared from preformed polymers as
active substances carriers is presented. This entails a general review of the different …

[HTML][HTML] PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: Effects of formulation parameters

KY Hernández-Giottonini, RJ Rodríguez-Córdova… - Rsc Advances, 2020 - pubs.rsc.org
This study presents the influence of the primary formulation parameters on the formation of
poly-DL-lactic-co-glycolic nanoparticles by the emulsification-solvent evaporation, and the …

The importance of understanding the freezing step and its impact on freeze-drying process performance

G Assegehegn, E Brito-de la Fuente, JM Franco… - Journal of …, 2019 - Elsevier
The freeze-drying process is a combination of 2 equally important processes, freezing, and
drying. In the past, the effort was mainly focused on optimizing the drying process without …

Freeze-drying of nanoparticles: formulation, process and storage considerations

W Abdelwahed, G Degobert, S Stainmesse… - Advanced drug delivery …, 2006 - Elsevier
Freeze-drying has been considered as a good technique to improve the long-term stability of
colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a …

Methods for the preparation and manufacture of polymeric nanoparticles

C Vauthier, K Bouchemal - Pharmaceutical research, 2009 - Springer
This review summarizes the different methods of preparation of polymer nanoparticles
including nanospheres and nanocapsules. The first part summarizes the basic principle of …

Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells

MM Yallapu, BK Gupta, M Jaggi… - Journal of colloid and …, 2010 - Elsevier
Curcumin, a natural polyphenolic compound, has shown promising chemopreventive and
chemotherapeutic activities in cancer. Although phase I clinical trials have shown curcumin …

Scaffold mean pore size influences mesenchymal stem cell chondrogenic differentiation and matrix deposition

A Matsiko, JP Gleeson, FJ O'Brien - Tissue Engineering Part A, 2015 - liebertpub.com
Recent investigations into micro-architecture of scaffolds has revealed that mean pore sizes
are cell-type specific and influence cellular shape, differentiation, and extracellular matrix …

Facts and evidences on the lyophilization of polymeric nanoparticles for drug delivery

P Fonte, S Reis, B Sarmento - Journal of controlled release, 2016 - Elsevier
Lyophilization has been used to improve the long-term stability of polymeric nanoparticles
for drug delivery applications, avoiding their instability in suspension. However, this …

Freeze-drying: A flourishing strategy to fabricate stable pharmaceutical and biological products

KK Abla, MM Mehanna - International journal of pharmaceutics, 2022 - Elsevier
Freeze-drying (FD) of nanoparticles, microorganisms, genes, and vaccines is an auspicious
technique used to enhance long-term stability and facilitate transportation mainly for …