Early detection has the potential to reduce cancer mortality, but an effective screening test
must demonstrate asymptomatic cancer detection years before conventional diagnosis in a …

Background Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate
primarily due to the late onset of symptoms and rapid progression. Reliable and accurate …

Background Obesity predisposes individuals to multiple cardiometabolic disorders,
including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat …

Sharing a common DNA binding motif called T‐box, transcription factor T‐box gene family
controls embryonic development and is also involved in cancer progression and metastasis …

Background Chemoresistance is a critical risk problem for breast cancer treatment.
However, mechanisms by which chemoresistance arises remains to be elucidated. The …

Homeobox genes encode transcription factors which regulate basic processes in
development and cell differentiation and are grouped into classes and subclasses according …

T-box transcription factor 15 (TBX15) is upregulated in a variety of tumors and has been
reported to promote uncontrolled proliferation of tumor cells and induce tumor cells to avoid …

OBJECTIVE: To investigate the role of microRNA-212-5p (miR-212-5p) in clear cell renal
cell carcinoma (ccRCC) and to explore the potential underlying mechanisms. MATERIALS …

Abstract Background/Objectives Screening patients with intraductal papillary mucinous
neoplasms (IPMN) has the primary goal of identifying potentially curable noninvasive …

TBX15, which encodes a differentiation-related transcription factor, displays promoter-
adjacent DNA hypermethylation in myoblasts and skeletal muscle (psoas) that is absent …