Through the representation of small molecule structures as numerical descriptors and the
exploitation of the similarity principle, chemoinformatics has made paramount contributions …

Cognitive impairments, such as learning and memory deficits, may occur in susceptible
populations including the elderly and patients who are chronically ill or have experienced …

The pan Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor fasudil acts
as a vasodilator and has been used as a medication for post-cerebral stroke for the past 29 …

Neurodegenerative disorders (NDs) have become increasingly common during the past
three decades. Approximately 15% of the total population of the world is affected by some …

Transgenic models are useful tools for studying the pathogenesis of and drug development
for Alzheimer's Disease (AD). AD models are constructed usually using overexpression or …

The incidence rate of nervous system diseases has increased in recent years. Nerve injury
or neurodegenerative diseases usually cause neuronal loss and neuronal circuit damage …

Alzheimer's disease is the most common form of dementia and is associated with the
accumulation of amyloid peptide β in the brain parenchyma. Vascular damage and …

Background: Alzheimer's disease (AD), the most common form of dementia, remains long-
term and challenging to diagnose. Furthermore, there is currently no medication to …

Alzheimer's disease (AD) is a progressive, irreversible, neurodegenerative disease that has
a profound impact on memory, reasoning, learning, and organizational abilities …

阿尔茨海默病(Alzheimer's disease, AD) 是一种复杂的, 起病隐秘的, 病因不明的,
缺乏特异性诊断方式的神经退行性病变. 面对与日俱增的患病率, 却缺乏有效的治疗方式 …