This article describes the pathophysiology and potential treatments for Gulf War Illness
(GWI), which is a chronic neuropsychiatric illness linked to a combination of chemical …

Radial glial cells (RGCs) are progenitors of the cerebral cortex which produce both neurons
and glia during development. Given their central role in development, RGC dysfunction can …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder.
Separate lines of evidence suggest that synapses and astrocytes play a role in the …

The in vivo physiological function of liquid–liquid phase separation (LLPS) that governs non–
membrane-bound structures remains elusive. Among LLPS-prone proteins, TAR DNA …

Pharmacological upregulation of glutamate transporter-1 (GLT-1), commonly achieved using
the beta-lactam antibiotic ceftriaxone, represents a promising therapeutic strategy to …

Functionally distinct synapses exhibit diverse and complex organisation at molecular and
nanoscale levels. Synaptic diversity may be dependent on developmental stage, anatomical …

Background The lack of effective treatment options for Alzheimer's disease (AD) is of
momentous societal concern. Synaptic loss is the hallmark of AD that correlates best with …

Gulf War illness is associated with a combination of exposure to war-related chemical
agents and traumatic stress. Currently, there are no effective treatments, and the …

Gulf War illness (GWI) is a chronic and multi-symptomatic disorder affecting veterans who
served in the Gulf War. The commonly reported symptoms in GWI veterans include mood …

Introduction We previously discovered a pyridazine derivative compound series that can
improve cognitive functions in mouse models of Alzheimer's disease. One of the advanced …