5,503,627 A 4/1996 McKinnon etal. 6,399,754 B1 6/2002 C001< _ 5,512,600 A 4/1996
M1kose1a1. 6,403,779 B1 6/2002 Kawasakl et al. 5,514,378 A 5/1996 M1koseta1 …

2008-11-17 Assigned to THE BRIGHAM AND WOMEN'S HOSPITAL, INC. reassignment
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ASSIGNMENT OF ASSIGNORS …

2013-03-26 Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY reassignment
MASSACHUSETTS INSTITUTE OF TECHNOLOGY ASSIGNMENT OF ASSIGNORS …

The present invention generally relates to polymers and mac romolecules, in particular, to
block polymers useful in par ticles Such as nanoparticles. One aspect of the invention is …

2010-07-19 Assigned to THE BRIGHAM AND WOMEN'S HOSPITAL, INC. reassignment
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ASSIGNMENT OF ASSIGNORS …

The present invention provides a drug delivery system for targeted delivery of therapeutic
agent-containing particles to tissues, cells, and intracellular compartments. The invention …

2010-01-12 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

5,174.930 A 12/1992 Stainmesse 6,095,148 A 8, 2000 Shastri et al. 5,175,296 A 12/1992
Gerster 6,107,094. A 8/2000 Crooke 5, 190,521. A 3/1993 Hubbard et al. 6,110,462 A …

A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene
therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed …

2013-12-31 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …