Obesity develops when energy intake exceeds energy expenditure over time. Numerous
neurotransmitters, hormones, and factors have been implicated to coordinately control …

Neuropeptide Y (NPY) is a highly conserved neuropeptide with orexigenic actions in
discrete hypothalamic nuclei that plays a role in regulating energy homeostasis. NPY …

Aims/hypothesis Metabolic disorders are commonly investigated using knockout and
transgenic mouse models. A variety of mouse strains have been used for this purpose …

Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the
human central and peripheral nervous systems. It consists of 36 highly conserved amino …

The neuropeptide Y (NPY) system–comprising of neuropeptide Y, peptide YY, pancreatic
polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and …

The importance of neuropeptide Y (NPY) and Y2 receptors in the regulation of bone and
energy homeostasis has recently been demonstrated. However, the contributions of the …

The neuropeptide Y system has proven to be one of the most important regulators of feeding
behaviour and energy homeostasis, thus presenting great potential as a therapeutic target …

Skeletal research is currently undergoing a period of marked expansion. The boundaries of
“bone” research are being re-evaluated and with this, a growing recognition of a more …

Obesity is a serious public health problem throughout the world, affecting both developed
societies and developing countries. The central nervous system has developed a …

There is growing evidence that neuropeptide Y (NPY) acting through Y1 and Y2 receptors
has a prominent role in modulating anxiety-and depression-like behavior in rodents …