Understanding and manipulating the separation in hydrophilic interaction liquid chromatography

DV McCalley - Journal of chromatography A, 2017 - Elsevier
Hydrophilic interaction liquid chromatography (HILIC) has emerged as a valuable
complimentary technique to reversed-phase (RP), being especially suited for the analysis of …

[HTML][HTML] Trends in sample preparation and separation methods for the analysis of very polar and ionic compounds in environmental water and biota samples

S Knoll, T Rösch, C Huhn - Analytical and bioanalytical chemistry, 2020 - Springer
Recent years showed a boost in knowledge about the presence and fate of micropollutants
in the environment. Instrumental and methodological developments mainly in liquid …

[HTML][HTML] Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry

M Huang, X Xu, H Qiu, N Li - Journal of Chromatography A, 2021 - Elsevier
Liquid chromatography-mass spectrometry has been widely implemented as a powerful tool
for providing in-depth characterization of nucleic acid therapeutic modalities, such as anti …

Growth years and post-harvest processing methods have critical roles on the contents of medicinal active ingredients of Scutellaria baicalensis

C Bai, J Yang, B Cao, Y Xue, P Gao, H Liang… - Industrial crops and …, 2020 - Elsevier
Optimizing the processing technology is an effective way to improve the yield of active
ingredients for the industrial production of medicinal crops. Baikal Skullcap (Scutellaria …

Hydrophilic interaction chromatography for the analysis of biopharmaceutical drugs and therapeutic peptides: A review based on the separation characteristics of the …

T Ikegami - Journal of separation science, 2019 - Wiley Online Library
Applications of hydrophilic interaction chromatography for the analysis of biopharmaceutical
drugs, ie, glycosylated proteins represented by monoclonal antibodies are discussed in the …

Hydrophilic interaction liquid chromatography promotes the development of bio-separation and bio-analytical chemistry

Q Sheng, M Liu, M Lan, G Qing - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Hydrophilic interaction liquid chromatography (HILIC) has inherent advantages in the
separation of hydrophilic or strongly polar substances (eg, saccharides, glycopeptides …

A study of column equilibration time in hydrophilic interaction chromatography

DV McCalley - Journal of Chromatography A, 2018 - Elsevier
The time taken to achieve full column equilibration for isocratic analysis of acidic, basic, and
neutral solutes in hydrophilic interaction liquid chromatography (HILIC) was compared using …

Graph convolutional networks for improved prediction and interpretability of chromatographic retention data

A Kensert, R Bouwmeester, K Efthymiadis… - Analytical …, 2021 - ACS Publications
Machine learning is a popular technique to predict the retention times of molecules based
on descriptors. Descriptors and associated labels (eg, retention times) of a set of molecules …

Characterization of a highly stable zwitterionic hydrophilic interaction chromatography stationary phase based on hybrid organic–inorganic particles

TH Walter, BA Alden, K Berthelette… - Journal of …, 2022 - Wiley Online Library
We have characterized a sulfobetaine stationary phase based on 1.7 μm ethylene‐bridged
hybrid organic–inorganic particles, which is intended for use in hydrophilic interaction …

Contribution of ionic interactions to stationary phase selectivity in hydrophilic interaction chromatography

M Gilar, KD Berthelette… - Journal of Separation …, 2022 - Wiley Online Library
We compared the separation selectivities of 19 different hydrophilic interaction
chromatography columns. The stationary phases included underivatized silica and hybrid …