Prevalence of and mortality from human immunodeficiency virus type 2 in Bissau, West Africa

AG Poulsen, P Aaby, K Frederiksen, B Kvinesdal… - The Lancet, 1989 - Elsevier
In a community based prevalence study of HIV infection in Bissau, West Africa, 1987, the
population in 100 randomly selected" houses" was asked to participate. 89%(1329/1499) …

Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer

PY Pan, G Ma, KJ Weber, J Ozao-Choy, G Wang, B Yin… - Cancer research, 2010 - AACR
Immune tolerance to tumors is often associated with accumulation of myeloid-derived
suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In …

Reduced rate of disease development after HIV-2 infection as compared to HIV-1

R Marlink, P Kanki, I Thior, K Travers, G Eisen, T Siby… - Science, 1994 - science.org
Human immunodeficiency virus type-2 (HIV-2) is a close relative of the prototype acquired
immunodeficiency syndrome (AIDS) virus, HIV-1. HIV-2 is biologically similar to HIV-1, but …

Slower heterosexual spread of HIV-2 than HIV-1

PJ Kanki, KU Travers, RG Marlink, ME Essex, S MBoup… - The Lancet, 1994 - Elsevier
Because of the similar virological properties of HIV types 1 and 2, HIV-2 was assumed to be
as infectious and capable of inducing AIDS as HIV-1. Seroepidemiological studies have …

[HTML][HTML] Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1

M Schindler, J Münch, O Kutsch, H Li, ML Santiago… - Cell, 2006 - cell.com
High-level immune activation and T cell apoptosis represent a hallmark of HIV-1 infection
that is absent from nonpathogenic SIV infections in natural primate hosts. The mechanisms …

Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology

F Gao, L Yue, DL Robertson, SC Hill, H Hui… - Journal of …, 1994 - Am Soc Microbiol
The virulence properties of human immunodeficiency virus type 2 (HIV-2) are known to vary
significantly and to range from relative attenuation in certain individuals to high-level …

Comparison of HIV‐1 and HIV‐2 infectivity from a prospective cohort study in Senegal

PB Gilbert, IW McKeague, G Eisen… - Statistics in …, 2003 - Wiley Online Library
From a prospective cohort study of 1948 initially human immunodeficiency virus (HIV)
uninfected female commercial sex workers followed between 1985 and 1999 in Dakar …

Infection with HIV-2

PJ Bock, DM Markovitz - Aids, 2001 - journals.lww.com
In 1985, a group of healthy Senegalese whose sera demonstrated much stronger antibody
responses to simian immunodeficiency virus (SIV) than to the HIV type 1 (HIV-1) was first …

Natural protection against HIV-1 infection provided by HIV-2

K Travers, S Mboup, R Marlink, A Guèye-Nidaye… - Science, 1995 - science.org
Significant differences have been observed in the rates of transmission and disease
development in human immunodeficiency virus (HIV) types 1 and 2. Because many HIV-2 …

Direct evidence of lower viral replication rates in vivo in human immunodeficiency virus type 2 (HIV-2) infection than in HIV-1 infection

A MacNeil, AD Sarr, JL Sankalé, ST Meloni… - Journal of …, 2007 - Am Soc Microbiol
Studies have shown that human immunodeficiency virus type 2 (HIV-2) is less pathogenic
than HIV-1, with a lower rate of disease progression. Similarly, plasma viral loads are lower …