Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic–pituitary–ovarian axis
X Chen, Z Xiao, Y Cai, L Huang, C Chen - Trends in endocrinology & …, 2022 - cell.com
Ovulatory disorders are the most common clinical feature exhibited among obese women.
Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone …
Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone …
Kisspeptin/kisspeptin receptor system in the ovary
Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …
NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice
K Chachlaki, A Messina, V Delli, V Leysen… - Science translational …, 2022 - science.org
The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the
regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for …
regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for …
Female sexual behavior in mice is controlled by kisspeptin neurons
V Hellier, O Brock, M Candlish, E Desroziers… - Nature …, 2018 - nature.com
Sexual behavior is essential for the survival of many species. In female rodents, mate
preference and copulatory behavior depend on pheromones and are synchronized with …
preference and copulatory behavior depend on pheromones and are synchronized with …
Connecting metabolism and gonadal function: novel central neuropeptide pathways involved in the metabolic control of puberty and fertility
Albeit essential for perpetuation of species, reproduction is an energy-demanding function
that can be adjusted to body metabolic status. Reproductive maturation and function can be …
that can be adjusted to body metabolic status. Reproductive maturation and function can be …
Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron
Signaling between kisspeptin and its receptor, G-protein-coupled receptor 54 (Gpr54), is
now recognized as being essential for normal fertility. However, the key cellular location of …
now recognized as being essential for normal fertility. However, the key cellular location of …
Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects
MN Lehman, SM Hileman, RL Goodman - Kisspeptin signaling in …, 2013 - Springer
Our understanding of kisspeptin and its actions depends, in part, on a detailed knowledge of
the neuroanatomy of the kisspeptin signaling system in the brain. In this chapter, we will …
the neuroanatomy of the kisspeptin signaling system in the brain. In this chapter, we will …
A microRNA switch regulates the rise in hypothalamic GnRH production before puberty
A sparse population of a few hundred primarily hypothalamic neurons forms the hub of a
complex neuroglial network that controls reproduction in mammals by secreting the'master …
complex neuroglial network that controls reproduction in mammals by secreting the'master …
Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators
J Roa, M Tena-Sempere - Molecular and cellular endocrinology, 2014 - Elsevier
It is well established that pubertal activation of the reproductive axis and maintenance of
fertility are critically dependent on the magnitude of body energy reserves and the metabolic …
fertility are critically dependent on the magnitude of body energy reserves and the metabolic …
Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation
BACKGROUND Initially identified as suppressors of metastasis in various types of cancer,
kisspeptins are a family of neuropeptides that are key regulators of the mammalian …
kisspeptins are a family of neuropeptides that are key regulators of the mammalian …