Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

The human body is inhabited by a diverse microbial community that is collectively coined as
commensal microbiota. Recent research has greatly advanced our understanding of how …

Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component
of most organoid tissue culture. However, it has limited the utility of organoids for drug …

Our knowledge regarding the contribution of the innate immune system in recognizing and
subsequently initiating a host response to an invasion of RNA virus has been rapidly …

Arteriviruses are positive-stranded RNA viruses that infect mammals. They can cause
persistent or asymptomatic infections, but also acute disease associated with a respiratory …

Among animals used in research, teaching and testing, mice are now widely recognized as
the most important model for human diseases and disorders. They comprise the majority of …

The intestine performs functions central to human health by breaking down food and
absorbing nutrients while maintaining a selective barrier against the intestinal microbiome …

B cell–dependent immunity to rotavirus, an important intestinal pathogen, plays a significant
role in viral clearance and protects against reinfection. Human in vitro and murine in vivo …

Most pathogens gain access to the host through surfaces of the body that are exposed to the
surrounding environment and rife with resident microorganisms, termed microbiota …

Innate immune sensors are required for induction of pathogen-specific immune responses.
Retroviruses are notorious for their ability to evade immune defenses and establish long …