Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …

Mechanical forces influence different cell types in our bodies. Among the earliest forces
experienced in mammals is blood movement in the vascular system. Blood flow starts at the …

During sprouting angiogenesis, an individual endothelial tip cell grows out from a pre-
existing vascular network and guides following and proliferating stalk cells to form a new …

Lactate generated from pyruvate fuels production of intracellular NAD+ as an end result of
the glycolytic process in tumors. Elevated lactate concentration represents a good indicator …

Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although
this metabolic conversion may primarily represent a rescue pathway to meet the …

The vascular system has the critical function of supplying tissues with nutrients and clearing
waste products. To accomplish these goals, the vasculature must be sufficiently permeable …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Moyamoya disease (MMD) is a unique cerebrovascular disease characterized by the
progressive stenosis of large intracranial arteries and a hazy network of basal collaterals …

Objective—Vascular cells, particularly endothelial cells, adopt aerobic glycolysis to generate
energy to support cellular functions. The effect of endothelial glycolysis on angiogenesis …

The placenta is a gender-specific transitory organ with the sole purpose of enabling the
growth and development of the fetus. It mediates the efficient transfer and exchange of …