The nucleolus is the most prominent nuclear body and serves a fundamentally important
biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to …

This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …

Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …

The 3D organization of chromatin regulates many genome functions. Our understanding of
3D genome organization requires tools to directly visualize chromatin conformation in its …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Enclosed by two membranes, the nucleus itself is comprised of various membraneless
compartments, including nuclear bodies and chromatin domains. These compartments play …

The nucleus is an essential organelle for the function of cells. It holds most of the genetic
material and plays a crucial role in the regulation of cell growth and proliferation. Since …

Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …

Ki-67 is one of the most famous marker proteins used by histologists to identify proliferating
cells. Indeed, over 30 000 articles referring to Ki-67 are listed on PubMed. Here, we review …

The nucleolus is the largest membrane-less structure in the eukaryotic nucleus. It is involved
in the biogenesis of ribosomes, essential macromolecular machines responsible for …