The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …

Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells.
In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis …

Arginine-rich cell-penetrating peptides (AR-CPPs) are very promising tools for the delivery of
therapeutic macromolecules such as peptides, proteins, and nucleic acids. These peptides …

Many therapeutics require efficient cytosolic delivery either because the receptors for those
drugs are located in the cytosol or their site of action is an intracellular organelle that …

The recombinant HIV-1 Tat protein contains a small region corresponding to residues
47YGRKKRRQRR57R, which is capable of translocating cargoes of different molecular …

Therapeutic peptides are attracting increasing attention for biomedical applications.
Peptides present promising opportunities in targeted drug delivery due to their high …

The ability of a drug or probe to cross a biological barrier has historically been viewed to be
a function of its intrinsic physical properties. This view has largely restricted drug design and …

Cell penetrating peptides hold considerable potential for academic and pharmaceutical
remits with an interest in delivering macromolecules to the insides of cells. Hundreds of …

The exact mechanisms by which arginine-rich cell-penetrating peptides enter cells are still
the subject of debate. Here, we have analyzed in detail the effects of serum and extracellular …