Gliomas are the most common primary intracranial tumor, representing 81% of malignant
brain tumors. Although relatively rare, they cause significant mortality and morbidity …

Background Primary central nervous system (CNS) tumors are a heterogeneous group of
neoplasms, including benign and malignant tumors. Since there are many heterogeneities …

Background Regularly updated epidemiological data on the burden of brain and central
nervous system (CNS) cancers are important in the prioritization of research and the …

Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy.
Standard therapeutic approaches provide modest improvement in progression-free and …

Insular gliomas represent a unique surgical challenge due to the complex anatomy and
nearby vascular elements associated within the Sylvian fissure. For certain tumors, the …

Glioblastoma multiforme (GBM) is a malignant glioma, difficult to detect and with the lowest
survival rates among gliomas. Its greater incidence among men and its higher survival rate …

Purpose There is large variability in reported incidence rates of primary brain/CNS tumors
across the world, with mostly higher rates in higher-income countries. The aim was to …

The key signaling networks regulating glioma cell proliferation remain poorly defined. The
leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) has been implicated in …

Objective In recent years, gamma knife radiosurgery (GKRS) has become increasingly more
popular as a salvage treatment modality for patients diagnosed with recurrent gliomas. The …

Abstract Gas (SF6)-filled microbubbles (MBs) were prepared by emulsion and solvent-
evaporation method. The prepared MBs were further conjugated with doxorubicin (Dox) …