Several studies have investigated the antinociceptive, immunomodulatory and anti-
inflammatory properties of compounds found in the lavender essential oil (LEO), however to …

Quality of evidence is an important consideration when making a therapeutic decision, in
that it is the best predictor of consistent clinical outcome. Quality of evidence can be graded …

Combinations of analgesics with different mechanisms of action offer the possibility of
efficient analgesia with a decrease in side effects as a result of reduced dosages of one or …

Drug combination for the treatment of pain is common clinical practice. Co-crystal of
Tramadol-Celecoxib (CTC) consists of two active pharmaceutical ingredients (APIs), namely …

In order to detect an anti-nociceptive interaction between morphine and gabapentin, the anti-
allodynic and anti-hyperalgesic effects of these drugs, administered either separately or in …

Combinations of two analgesic drugs of the same or different class are widely used in
clinical therapy to enhance its antinociceptive effects and reduce the side effects. In order to …

The purpose of this work was to evaluate the antinociceptive efficacy of an optimal morphine
and metamizol combination on different levels of nociception (levels I, II, and III) using the …

Dexketoprofen and tramadol, alone or in combination, were evaluated after oral or intra-
articular administration on knee osteoarthritis nociception induced by intra-articular (i. ar.) …

Neuropathic pain is characterized by the presence of hyperalgesia and allodynia.
Pharmacological treatments include the use of antiepileptics such as pregabalin or …

This study was designed to evaluate the antinociceptive interaction of the tramadol–
meloxicam combination in different proportions (tramadol+ meloxicam in 1: 1, 1: 3, and 3: 1 …