Noble metals in medicine: Latest advances

S Medici, M Peana, VM Nurchi, JI Lachowicz… - Coordination Chemistry …, 2015 - Elsevier
History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

Perspective: the potential of pyrazole-based compounds in medicine

FK Keter, J Darkwa - Biometals, 2012 - Springer
Pyrazoles are widely used as core motifs for a large number of compounds for various
applications such as catalysis, agro-chemicals, building blocks of other compounds and in …

Comprehensive review on tumour active palladium compounds and structure–activity relationships

MN Alam, F Huq - Coordination Chemistry Reviews, 2016 - Elsevier
This article provides a comprehensive review of palladium compounds that have been
evaluated for anticancer activity in vivo or in vitro from the era of discovery of cisplatin up to …

Anti-cancer activity of a novel palladium (II) complex on human breast cancer cells in vitro and in vivo

E Ulukaya, F Ari, K Dimas, EI Ikitimur, E Guney… - European journal of …, 2011 - Elsevier
Anti-cancer effects of a newly-synthesized palladium (II) complex,[Pd (sac)(terpy)](sac)·
4H2O (sac= saccharinate, and terpy= 2, 2′: 6′, 2 ″-terpyridine), were tested against …

A novel series of pyrazole-platinum (II) complexes as potential anti-cancer agents that induce cell cycle arrest and apoptosis in breast cancer cells

R Czarnomysy, A Surażyński… - Journal of enzyme …, 2018 - Taylor & Francis
Six novel compounds of platinum (II) with pyrazole derivatives PtPz1–PtPz6 were
synthesised and characterised (PtPz1-[Pt2N-hydroksymethyl-3, 5-dimethylpyrazole4 …

Organometallic palladium complexes with a water-soluble iminophosphorane ligand as potential anticancer agents

M Carreira, R Calvo-Sanjuan, M Sanau, I Marzo… - …, 2012 - ACS Publications
The synthesis and characterization of a new water-soluble iminophosphorane ligand TPA
NC (O)-2BrC6H4 (1, C, N-IM; TPA= 1, 3, 5-triaza-7-phosphaadamantane) is reported …

Platinum (II) and palladium (II) complexes with (N, N′) and (C, N, N′)− ligands derived from pyrazole as anticancer and antimalarial agents: Synthesis …

J Quirante, D Ruiz, A Gonzalez, C López… - Journal of Inorganic …, 2011 - Elsevier
The study of the reactivity of three 1-(2-dimethylaminoethyl)-1H-pyrazole derivatives of
general formula [1-(CH2) 2NMe2}-3, 5-R2-pzol]{where pzol represents pyrazole and RH …

Synthesis, characterization, structures and cytotoxic activity of palladium (II) and platinum (II) complexes containing bis (2-pyridylmethyl) amine and saccharinate

E Guney, VT Yilmaz, F Ari, O Buyukgungor, E Ulukaya - Polyhedron, 2011 - Elsevier
New palladium (II) and platinum (II) complexes containing bis (2-pyridylmethyl) amine
(bpma) and saccharinate (sac),[Pd (bpma)(sac)](sac)· 2H2O (1),[Pt (bpma)(sac)](sac)· 2H2O …

Cell death-inducing effect of novel palladium (II) and platinum (II) complexes on non-small cell lung cancer cells in vitro

E Ulukaya, F Ari, K Dimas, M Sarimahmut… - Journal of cancer …, 2011 - Springer
Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need
for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd …

Anticancer behaviour of 2, 2′-(pyridin-2-ylmethylene) bis (5, 5-dimethylcyclohexane-1, 3-dione)-based palladium (II) complex and its DNA, BSA binding propensity …

MA Ragheb, MH Soliman, IA Abdelhamid… - Journal of Inorganic …, 2024 - Elsevier
Herein, we report the synthesis and biological evaluation of [Pd (L)(OH 2) Cl] complex
(where L= 2, 2′-(pyridin-2-ylmethylene) bis (5, 5-dimethylcyclohexane-1, 3-dione) as a …