Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …

The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

As the most apical structure between epithelial and endothelial cells, tight junctions (TJ) are
well known as functioning as a control for the paracellular diffusion of ions and certain …

Central nervous system (CNS) involvement remains an important cause of morbidity and
mortality in acute leukemia, the mechanisms of leukemic cell infiltration into the CNS have …

Over the last two decades, since the initial discovery of human papillomavirus (HPV) type 16
and 18 DNAs in cervical cancers by Dr. Harald zur Hausen (winner of the Nobel Prize in …

Intercellular tight junctions define epithelial apicobasal polarity and form a physical fence
which protects underlying tissues from pathogen invasions. PALS1, a tight junction …

The evolutionarily conserved Crumbs protein complex is a key regulator of cell polarity and
cell shape in both invertebrates and vertebrates. The important role of this complex in …

Tight junctions (TJs) are morphologically distinct and highly regulated areas of close contact
between the plasma membranes of neighbouring epithelial and endothelial cells. They are …