Nucleosome structure and dynamics are coming of age
Since the first high-resolution structure of the nucleosome was reported in 1997, the
available information on chromatin structure has increased very rapidly. Here, we review …
available information on chromatin structure has increased very rapidly. Here, we review …
The four causes: the functional architecture of centromeres and kinetochores
AD McAinsh, AL Marston - Annual review of genetics, 2022 - annualreviews.org
Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A)
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …
Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization
Centromeres are specialized chromosome loci that seed the kinetochore, a large protein
complex that effects chromosome segregation. A 16-subunit complex, the constitutive …
complex that effects chromosome segregation. A 16-subunit complex, the constitutive …
[HTML][HTML] Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome
In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome
stability and prevents aneuploidy. Kinetochores are large protein complexes that, by …
stability and prevents aneuploidy. Kinetochores are large protein complexes that, by …
Contributions of histone variants in nucleosome structure and function
H Kurumizaka, T Kujirai, Y Takizawa - Journal of molecular biology, 2021 - Elsevier
Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …
CENP-N promotes the compaction of centromeric chromatin
The histone variant CENP-A is the epigenetic determinant for the centromere, where it is
interspersed with canonical H3 to form a specialized chromatin structure that nucleates the …
interspersed with canonical H3 to form a specialized chromatin structure that nucleates the …
Structural mechanism of LIN28B nucleosome targeting by OCT4
Pioneer transcription factors are essential for cell fate changes by targeting closed
chromatin. OCT4 is a crucial pioneer factor that can induce cell reprogramming. However …
chromatin. OCT4 is a crucial pioneer factor that can induce cell reprogramming. However …
The IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic glycolysis
CL Qi, ML Huang, Y Zou, R Yang, Y Jiang… - Journal of Experimental …, 2021 - Springer
Abstract Background Centromere protein N (CENP-N) has been reported to be highly
expressed in malignancies, but its role and mechanism in nasopharyngeal carcinoma (NPC) …
expressed in malignancies, but its role and mechanism in nasopharyngeal carcinoma (NPC) …
The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle
Eukaryotic chromosome segregation relies upon specific connections from DNA to the
microtubule-based spindle that forms at cell division. The chromosomal locus that directs …
microtubule-based spindle that forms at cell division. The chromosomal locus that directs …