The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Oxygen (O2) is essential for human life. Molecular oxygen is vital for the production of
adenosine triphosphate (ATP) in human cells. O2 deficiency leads to a reduction in the …

Sensory neurons initiate defensive reflexes that ensure airway integrity. Dysfunction of
laryngeal neurons is life-threatening, causing pulmonary aspiration, dysphagia, and …

Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Maintenance of homeostasis in the respiratory and cardiovascular systems depends on
reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in …

Mammalian carotid body arterial chemoreceptors function as an early warning system for
hypoxia, triggering acute life-saving arousal and cardiorespiratory reflexes. To serve this …

Reflex increases in breathing in response to acute hypoxia are dependent on activation of
the carotid body (CB)—A specialised peripheral chemoreceptor. Central to CB O2-sensing …

It is generally acknowledged that the carotid body (CB) type I cell mitochondria are unique,
being inhibited by relatively small falls in PaO2 well above those known to inhibit electron …

Aim Numerous studies have shown that H2S serves as an acute oxygen sensor in a variety
of cells. We hypothesize that H2S also serves in extended oxygen sensing. Methods Here …

Mammalian carotid bodies (CB) are chemosensory organs that mediate compensatory
cardiorespiratory reflexes in response to low blood PO2 (hypoxemia) and elevated CO2/H+ …