[HTML][HTML] Negative feedback control of neuronal activity by microglia
Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …
dying neurons, pruning non-functional synapses, and producing ligands that support …
[HTML][HTML] Temporal progress of gene expression analysis with RNA-Seq data: A review on the relationship between computational methods
Abstract Analysis of differential gene expression from RNA-seq data has become a standard
for several research areas. The steps for the computational analysis include many data …
for several research areas. The steps for the computational analysis include many data …
Epigenetic regulation of brain region-specific microglia clearance activity
The rapid elimination of dying neurons and nonfunctional synapses in the brain is carried
out by microglia, the resident myeloid cells of the brain. Here we show that microglia …
out by microglia, the resident myeloid cells of the brain. Here we show that microglia …
The genome of Aiptasia, a sea anemone model for coral symbiosis
S Baumgarten, O Simakov… - Proceedings of the …, 2015 - National Acad Sciences
The most diverse marine ecosystems, coral reefs, depend upon a functional symbiosis
between a cnidarian animal host (the coral) and intracellular photosynthetic dinoflagellate …
between a cnidarian animal host (the coral) and intracellular photosynthetic dinoflagellate …
Transcriptomics in toxicogenomics, part II: preprocessing and differential expression analysis for high quality data
Preprocessing of transcriptomics data plays a pivotal role in the development of
toxicogenomics-driven tools for chemical toxicity assessment. The generation and …
toxicogenomics-driven tools for chemical toxicity assessment. The generation and …
PTBP1-mediated alternative splicing regulates the inflammatory secretome and the pro-tumorigenic effects of senescent cells
Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically,
senescence also induces an inflammatory secretome that promotes carcinogenesis and age …
senescence also induces an inflammatory secretome that promotes carcinogenesis and age …
Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
Commensal bacteria are critically involved in the establishment of tolerance against
inflammatory challenges, the molecular mechanisms of which are just being uncovered. All …
inflammatory challenges, the molecular mechanisms of which are just being uncovered. All …
Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity
N Yoshida, T Yamashita, T Osone, T Hosooka… - Iscience, 2021 - cell.com
The gut microbiome has emerged as a key regulator of obesity; however, its role in brown
adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We …
adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We …
miRmine: a database of human miRNA expression profiles
Motivation MicroRNAs (miRNAs) are small non-coding RNAs that are involved in post-
transcriptional regulation of gene expression. In this high-throughput sequencing era, a …
transcriptional regulation of gene expression. In this high-throughput sequencing era, a …
MLL4 is required to maintain broad H3K4me3 peaks and super-enhancers at tumor suppressor genes
Super-enhancers are large clusters of enhancers that activate gene expression. Broad
trimethyl histone H3 lysine 4 (H3K4me3) often defines active tumor suppressor genes …
trimethyl histone H3 lysine 4 (H3K4me3) often defines active tumor suppressor genes …