Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Pyroptosis: mechanisms and diseases

P Yu, X Zhang, N Liu, L Tang, C Peng… - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Pattern recognition receptors in health and diseases

D Li, M Wu - Signal transduction and targeted therapy, 2021 - nature.com
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD

JM Paik, P Golabi, Y Younossi, A Mishra… - Hepatology, 2020 - journals.lww.com
Conclusions Our findings indicate that LINC00665 is involved in the NF‐κB signaling
activation in HCC cells and that the inflammatory LINC00665/PKR/NF‐κB loop plays …

Chronic stress promotes cancer development

S Dai, Y Mo, Y Wang, B Xiang, Q Liao, M Zhou… - Frontiers in …, 2020 - frontiersin.org
Stress is an inevitable part of life. Chronic stress on account of reasons like adversity,
depression, anxiety, or loneliness/social isolation can endanger human health. Recent …

[HTML][HTML] The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

MR Zinatizadeh, B Schock, GM Chalbatani, PK Zarandi… - Genes & diseases, 2021 - Elsevier
The nuclear factor kappa B (NF-êB) family of transcription factors plays an essential role as
stressors in the cellular environment, and controls the expression of important regulatory …

NF-κB, inflammation, immunity and cancer: coming of age

K Taniguchi, M Karin - Nature Reviews Immunology, 2018 - nature.com
Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …