While chronic pain is considered by some to be a CNS disease, little is understood about
underlying neurobiological mechanisms. Addiction models have heuristic value in this …

Opioid use disorder (OUD) is a debilitating disorder that affects millions of people. Neutral
cues can acquire motivational properties when paired with the positive emotional effects of …

Alcohol use disorder is highly prevalent worldwide, with characteristically severe pain
sensitivity during withdrawal. Here, we established a mouse model of hyperalgesia during …

Chronic pain is a major public health problem and an economic burden worldwide.
However, its underlying pathological mechanisms remain unclear. MicroRNAs (miRNAs) are …

Opioids and alcohol are widely used to relieve pain, with their analgesic efficacy stemming
from rapid actions on both spinal and supraspinal nociceptive centers. As an extension of …

Chronic pain is among the most common reasons adults in the US seek medical care.
Despite chronic pain's substantial impact on individuals' physical, emotional, and financial …

Alcohol is an effective and widely utilized analgesic. However, the chronic use of alcohol
can actually facilitate nociceptive sensitivity over time, a condition known as hyperalgesia …

Previous experience of chronic pain causes enhanced responses to upcoming noxious
events in both humans and animals, but the underlying mechanisms remain unclear. In the …

Objective: Although the great majority of individuals who take opioids for chronic pain use
them appropriately and to good effect, a certain minority will develop the problematic …

Repeated use of opioids can lead to the development of analgesic tolerance and
dependence. Additionally, chronic opioid exposure can cause a paradoxical emergence of …