The first report demonstrating that prolonged endurance exercise promotes oxidative stress
in humans was published more than 4 decades ago. Since this discovery, many ensuing …

Background The absence of a single, identifiable traumatic cause has been traditionally
used as a definition for a causative factor of overuse injury. Excessive loading, insufficient …

The existence of free radicals in living cells was first reported in 1954 and this important
finding helped launch the field of free radical biology. However, the discovery that muscular …

The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

Repeated, intense use of muscles leads to a decline in performance known as muscle
fatigue. Many muscle properties change during fatigue including the action potential …

It is well established that contracting muscles produce both reactive oxygen and nitrogen
species. Although the sources of oxidant production during exercise continue to be debated …

Scientific advances in this field have not only given us a better understanding of what is an
optimal diet, but has allowed food and nutraceutical companies to market products with …

Atrogin1/MAFbx is an ubiquitin ligase that mediates muscle atrophy in a variety of catabolic
states. We recently found that H 2 O 2 stimulates atrogin1/MAFbx gene expression. Since …

Over the past decade, reactive oxygen species (ROS) and nitric oxide (NO) derivatives have
been established as physiological modulators of skeletal muscle function. This mini-review …

In 490 BC, the Persian Army landed on the plain of Marathon, 25 miles from Athens. The
Athenians sent a messenger named Feidipides to Sparta to ask for help. He ran the 150 …