The glomerular filtration barrier: a structural target for novel kidney therapies
IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19
X Bi, W Liu, X Ding, S Liang, Y Zheng, X Zhu, S Quan… - Cell reports, 2022 - cell.com
The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed
the proteome and metabolome of urine and serum samples from patients with COVID-19 …
the proteome and metabolome of urine and serum samples from patients with COVID-19 …
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
Regulation of the actin cytoskeleton in podocytes
J Blaine, J Dylewski - Cells, 2020 - mdpi.com
Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …
filtration of large proteins and macromolecules into the urine. Podocyte function is …
A molecular mechanism explaining albuminuria in kidney disease
L Butt, D Unnersjö-Jess, M Höhne, A Edwards… - Nature …, 2020 - nature.com
Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …
[HTML][HTML] SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy
P Cassis, M Locatelli, D Cerullo, D Corna, S Buelli… - JCI insight, 2018 - ncbi.nlm.nih.gov
Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors have pleiotropic properties
beyond blood glucose–lowering effects and modify important nonglycemic pathways …
beyond blood glucose–lowering effects and modify important nonglycemic pathways …
[HTML][HTML] Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis
Kidney involvement confers significant morbidity and mortality in patients with systemic
lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse …
lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse …
Sirtuins in renal health and disease
Sirtuins belong to an evolutionarily conserved family of NAD+-dependent deacetylases that
share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy …
share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy …
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney
Little is known about the molecular changes that take place in the kidney during the aging
process. In order to better understand these changes, we measured mRNA and protein …
process. In order to better understand these changes, we measured mRNA and protein …