Conspectus As the remit of chemistry expands beyond molecules to systems, new synthetic
targets appear on the horizon. Among these, life represents perhaps the ultimate synthetic …

We have been studying simple prebiotic catalytic replicating networks as prototypes for
modeling replication, complexification and Systems Chemistry. While living systems are …

The emergence of evermore complex entities from prebiotic building blocks is a key aspect
of origins of life research. The RNA-world hypothesis posits that RNA oligomers known as …

The RNA world is one of the principal hypotheses to explain the emergence of living
systems on the prebiotic Earth. It posits that RNA oligonucleotides acted as both carriers of …

Abstract Systems Chemistry generates platforms for studying the emergence of function in
networks operating far from equilibrium. In this area, we have previously used experiments …

Abstract Calcium (Ca 2+) and phosphate ions (PO 4 3−/P i) are indispensable for all
fundamental biological processes. The bones are the major reservoir of these ions in the …

Understanding how systems that can replicate information can emerge from the interaction
of informational polymers (DNA, RNA) is crucial to comprehend the origins of life on Earth …