Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of
schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an …
schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an …
[HTML][HTML] Glutamate in schizophrenia: Neurodevelopmental perspectives and drug development
Research into the neurobiological processes that may lead to the onset of schizophrenia
places growing emphasis on the glutamatergic system and brain development. Preclinical …
places growing emphasis on the glutamatergic system and brain development. Preclinical …
PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment
AA Coley, WJ Gao - Scientific Reports, 2019 - nature.com
Abstract Postsynaptic density protein-95 (PSD-95) is a major regulator in the maturation of
excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors …
excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors …
NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms
MA Snyder, WJ Gao - Schizophrenia research, 2020 - Elsevier
Schizophrenia (SZ) is a neurodevelopmental disorder with cognitive deficits manifesting
during early stages of the disease. Evidence suggests that genetic factors in combination …
during early stages of the disease. Evidence suggests that genetic factors in combination …
International union of basic and clinical pharmacology. CXI. Pharmacology, signaling, and physiology of metabotropic glutamate receptors
KJ Gregory, C Goudet - Pharmacological reviews, 2021 - ASPET
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …
Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research
MR Dauvermann, G Lee… - British journal of …, 2017 - Wiley Online Library
The pharmacological modulation of glutamatergic neurotransmission to improve cognitive
function has been a focus of intensive research, particularly in relation to the cognitive …
function has been a focus of intensive research, particularly in relation to the cognitive …
A review of molecular imaging of glutamate receptors
JH Kim, J Marton, SM Ametamey, P Cumming - Molecules, 2020 - mdpi.com
Molecular imaging with positron emission tomography (PET) and single photon emission
computed tomography (SPECT) is a well-established and important in vivo technique to …
computed tomography (SPECT) is a well-established and important in vivo technique to …
Activation of mGlu2/3 receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism
Selective blockade of serotonin 2A (5-HT 2A) receptors is a promising strategy to reduce L-
3, 4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia and has shown efficacy in a …
3, 4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia and has shown efficacy in a …
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome
We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
Prodromal memory deficits represent an important marker for the development of
schizophrenia (SZ), in which glutamatergic hypofunction occurs in the prefrontal cortex …
schizophrenia (SZ), in which glutamatergic hypofunction occurs in the prefrontal cortex …