Bacteriophage T4 as a Protein-Based, Adjuvant-and Needle-Free, Mucosal Pandemic Vaccine Design Platform

J Zhu, P Tao, AK Chopra, VB Rao - Annual Review of Virology, 2024 - annualreviews.org
The COVID-19 pandemic has transformed vaccinology. Rapid deployment of mRNA
vaccines has saved countless lives. However, these platforms have inherent limitations …

Carriers and antigens: new developments in glycoconjugate vaccines

RMF van der Put, B Metz, RJ Pieters - Vaccines, 2023 - mdpi.com
Glycoconjugate vaccines have proven their worth in the protection and prevention of
infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the …

Stereoselective Synthesis of Sialyl Lewisa Antigen and the Effective Anticancer Activity of Its Bacteriophage Qβ Conjugate as an Anticancer Vaccine

Z Rashidijahanabad, S Ramadan… - Angewandte Chemie …, 2023 - Wiley Online Library
Sialyl Lewisa (sLea), also known as cancer antigen 19‐9 (CA19‐9), is a tumor‐associated
carbohydrate antigen. The overexpression of sLea on the surface of a variety of cancer cells …

Virus-like Particle Display of Vibrio cholerae O-Specific Polysaccharide as a Potential Vaccine against Cholera

Z Rashidijahanabad, M Kelly… - ACS infectious …, 2022 - ACS Publications
Vibrio cholerae, a noninvasive mucosal pathogen, is endemic in more than 50 countries.
Oral cholera vaccines, based on killed whole-cell strains of Vibrio cholerae, can provide …

Enhancing Protective Antibodies against Opioids through Antigen Display on Virus-like Particles

F Shafieichaharberoud, S Lang, C Whalen… - Bioconjugate …, 2023 - ACS Publications
Opioid use disorder (OUD) has become a public health crisis, with recent significant
increases in the number of deaths due to overdose. Vaccination can provide an attractive …

Epitope-directed antibody elicitation by genetically encoded chemical cross-linking reactivity in the antigen

C Zhu, L Xu, L Chen, Z Zhang, Y Zhang… - ACS Central …, 2023 - ACS Publications
No current methods can selectively elicit an antibody response to a specific conformational
epitope in a whole antigen in vivo. Here, we incorporated N ε-acryloyl-l-lysine (AcrK) or N ε …

A comprehensive synthetic library of poly-N-acetyl glucosamines enabled vaccine against lethal challenges of Staphylococcus aureus

Z Tan, W Yang, NA O'Brien, X Pan, S Ramadan… - Nature …, 2024 - nature.com
Abstract Poly-β-(1–6)-N-acetylglucosamine (PNAG) is an important vaccine target,
expressed on many pathogens. A critical hurdle in developing PNAG based vaccine is that …

A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective

L Vuitika, N Côrtes, VB Malaquias, JDQ Silva, A Lira… - Scientific Reports, 2024 - nature.com
Vaccination has played a critical role in mitigating COVID-19. Despite the availability of
licensed vaccines, there remains a pressing need for improved vaccine platforms that …

Bacteriophages and their unique components provide limitless resources for exploitation

CM Szymanski - Frontiers in Microbiology, 2024 - frontiersin.org
Since the original discovery of bacteriophages by William Twort in 1915, and Félix d'Hérelle
in 1917, there have been numerous reports describing the use of these “filterable viruses” in …

Development of NHAcGD2/NHAcGD3 conjugates of bacteriophage MX1 virus-like particles as anticancer vaccines

Q Zhao, X Huang, X Wu - RSC advances, 2024 - pubs.rsc.org
The successful development of an anticancer vaccine will be a giant leap forward in cancer
prevention and treatment. Herein, the bacteriophage MX1 coat protein virus-like particles …