Immunology and immunotherapy of cholangiocarcinoma

TF Greten, R Schwabe, N Bardeesy, L Ma… - Nature Reviews …, 2023 - nature.com
Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …

Pathology and pathogenesis of metabolic dysfunction-associated steatotic liver disease-associated hepatic tumors

Y Takahashi, E Dungubat, H Kusano, T Fukusato - Biomedicines, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in
the livers of patients without a history of alcohol abuse. It is classified as either simple …

[HTML][HTML] Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

L Izquierdo-Sanchez, A Lamarca, A La Casta… - Journal of …, 2022 - Elsevier
Background & Aims Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer,
whose incidence and related mortality is increasing. This study investigates the clinical …

Patient healthcare trajectories of intrahepatic cholangiocarcinoma in France: A nationwide retrospective analysis

C Neuzillet, C Emery, C Teissier, S Bouée… - The Lancet Regional …, 2022 - thelancet.com
Background Little is known about the epidemiology and patterns of care of intrahepatic
cholangiocarcinoma (iCCA) in daily clinical practice. The aims of this study were to estimate …

Cholangiocarcinoma: Pathologic and molecular classification in the era of precision medicine

P Gopal, ME Robert, X Zhang - Archives of Pathology & …, 2024 - meridian.allenpress.com
Context.—Cholangiocarcinoma (CCA) is a heterogeneous cancer of the bile duct, and its
diagnosis is often challenging. Objective.—To provide insights into state-of-the-art …

Management of intrahepatic cholangiocarcinoma

S Kodali, A Shetty, S Shekhar, DW Victor… - Journal of Clinical …, 2021 - mdpi.com
Cholangiocarcinoma is a tumor that arises as a result of differentiation of the cholangiocytes
and can develop from anywhere in the biliary tree. Subtypes of cholangiocarcinoma are …

[HTML][HTML] Neoadjuvant and adjuvant therapy in intrahepatic cholangiocarcinoma

X Chen, J Du, J Huang, Y Zeng… - Journal of Clinical and …, 2022 - ncbi.nlm.nih.gov
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and
causes major economic and health burdens throughout the world. Although the incidence of …

Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies

JH Hong, CH Yong, HL Heng, JY Chan, MC Lau… - Gut, 2024 - gut.bmj.com
Objectives Cholangiocarcinoma (CCA) is a heterogeneous malignancy with high mortality
and dismal prognosis, and an urgent clinical need for new therapies. Knowledge of the CCA …

The recent trends of systemic treatments and locoregional therapies for cholangiocarcinoma

A Esmail, M Badheeb, BW Alnahar… - …, 2024 - pmc.ncbi.nlm.nih.gov
Cholangiocarcinoma (CCA) is a hepatic malignancy that has a rapidly increasing incidence.
CCA is anatomically classified into intrahepatic (iCCA) and extrahepatic (eCCA), which is …

Feedback signaling between cholangiopathies, ductular reaction, and non-alcoholic fatty liver disease

T Zhou, D Kundu, J Robles-Linares, V Meadows… - Cells, 2021 - mdpi.com
Fatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health
disparities, particularly in the United States, as a result of cultural eating habits and lifestyle …