Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS)
cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial …

In the past two decades, structural and functional neuroimaging findings have greatly
modified longstanding notions regarding the pathophysiology of amyotrophic lateral …

Bulbar impairment represents a hallmark feature of Amyotrophic Lateral Sclerosis (ALS) that
significantly impacts survival and quality of life. Speech and swallowing dysfunction are key …

Objective: We investigated a large sample of patients with amyotrophic lateral sclerosis
(ALS) at rest in order to assess the value of 18F-2-fluoro-2-deoxy-d-glucose (18F-FDG) PET …

Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …

Background and purpose Considerable functional reorganization takes place in
amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …

Objective: To describe the patterns of cortical and subcortical changes in amyotrophic lateral
sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center …

Although hippocampal involvement in amyotrophic lateral sclerosis (ALS) has been
consistently highlighted by postmortem studies, memory impairment remains under …