TDP1 and TDP2 were discovered and named based on the fact they process 3′-and 5′-
DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases …

Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …

Protein-and RNA-containing foci and aggregates are a hallmark of many age-and mutation-
related neurodegenerative diseases. This article focuses on the role the nucleolus has as a …

Despite recent efforts in discovering novel long non-coding RNAs (lncRNAs) and unveiling
their functions in a wide range of biological processes their applications as biotechnological …

The paramyxovirus matrix (M) protein is a molecular scaffold required for viral
morphogenesis and budding at the plasma membrane. Transient nuclear residence of some …

The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage
in which the topoisomerase is covalently linked to the 3′-or 5′-terminus of a DNA strand …

Parkinson's disease (PD) is the second most common neurodegenerative disorder.
Although the causes of PD are still not understood, aging is a predisposing factor and …

Parkinson's disease (PD) is one of the most common degenerative disorders of the central
nervous system that produces motor and non-motor symptoms. The majority of cases are …

TDP2 is a multifunctional enzyme previously known for its role in signal transduction as
TRAF and TNF receptor-associated protein (TTRAP) and ETS1-associated protein 2 (EAPII) …

The mechanisms by which protein complexes convert from functional to pathogenic are the
subject of intensive research. Here, we report how functionally unfavorable protein …