Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease
characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of …

FIG. 1. Neogenesis in mouse pancreas. A: The metaplastic ducts seen in the zinc-treated
metallothionen. TGF-transgenic mice have 6% insulin (red, white arrows) cells and some …

In neonatal Wistar rats injected with streptozotocin (STZ) at birth (n0-STZ model), a
recognized model of β-cell regeneration, we investigated the capacity of early treatment with …

Pancreatic organogenesis has been a classic example of epitheliomesenchymal
interactions. The nature of this interaction, and the way in which endocrine, acinar and …

We have identified a model system for the study of pancreatic islet development and
regeneration in transgenic mice bearing the interferon-gamma (IFN-g) gene expressed in …

Routine immunohistochemical analysis of human donor pancreata indicated the frequent
occurrence of single insulin-immunoreactive cells. In a quantitative analysis of nine organs …

Islet cell ontogeny will define adult β-cell mass and will consist of a balance of islet cell birth
and death. We have investigated the ontogeny of factors that may be related to …

Cytokeratins (CKs) serve as immunocytochemical markers of epithelial cells. We found that
duct cells of the neonatal and adult rat pancreas express CKs 7, 19, and 20. Because …

Regeneration of neonatal beta cells after streptozotocin (STZ)-induced destruction may be
due to either replication from pre-existing intra-islet beta cells or extra-islet precursor cells …

The pancreatic duct cell, although a minor cell type of the pancreas, plays an important role
in fluid/electrolyte and mucin secretion, and has been implicated in the development of …