Cascade testing is the process of offering genetic counseling and testing to at-risk relatives
of an individual who has been diagnosed with a genetic condition. It is critical for increasing …

Successful proband‐mediated family communication and subsequent cascade genetic
testing uptake requires interventions that present information clearly, in sufficient detail, and …

Abstract Purpose of Review Cascade testing, or screening, is the process of stepwise,
systematic genetic testing of at-risk relatives for a genetic variant originally identified in a …

Background Familial hypercholesterolemia (FH) is a serious genetic disorder affecting
approximately 1 in every 300 to 500 individuals and is characterised by excessively high low …

Inherited cardiac conditions (ICCs) can lead to sudden cardiac death at any age, yet are
often asymptomatic and clinically undetected. Prophylactic interventions are available and …

Purpose Family-based cascade screening from index probands is considered an effective
way of identifying undiagnosed individuals with familial hypercholesterolemia (FH). The role …

There is much attention and excitement in the current health care environment on the
potential of precision medicine based on a patient's genomic data. Today, what arguably …

Familial hypercholesterolemia (FH) is severely underdiagnosed in the USA; yet, factors
influencing family notification about risk for FH in the US pediatric setting have not been well …

This study explores perceptions and preferences on receiving genetic risk information about
hereditary cancer risk in members of the Swedish public. We conducted qualitative content …

The primary aim of this study was to test the feasibility of a public health screening program
to identify individuals at high risk of familial hypercholesterolemia through a novel screening …