Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction
in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the …

Xenotransplantation is very attractive strategy for addressing the shortage of donors. While
hyper acute rejection (HAR) caused by natural antibodies and complement has been well …

Insulin injection is currently the main therapy for type 1 diabetes (T1D) or late stage of
severe type 2 diabetes (T2D). Human pancreatic islet transplantation confers a significant …

Inhibition of Janus kinase 3 (JAK3), a member of the JAK family of tyrosine kinases, remains
an essential area of research for developing treatments for autoimmune diseases …

Abstract Background and Aims Inflammatory bowel diseases are highly debilitating
conditions that require constant monitoring and life-long medication. Current treatments are …

Abstract Purpose of Review Porcine islet xenotransplantation is a promising alternative to
overcome the shortage of organ donors. For the successful application of islet …

Objective To investigate the dual mechanism of islet transplantation in T1D by regulating the
immune tolerance of macrophages and inducing the neovascularization. Methods NC …

For those who work in the field of islet transplantation, the microvascular coronavirus
disease 2019 (COVID-19) lung vessels obstructive thrombo-inflammatory syndrome …

Porcine islet xenotransplantation has been highlighted as an alternative to allo islet
transplantation. Despite the remarkable progress that has been made in porcine‐islet pre …

Pancreatic islet transplantation (ITx) established proof of concept that cellular therapies are
feasible options to manage intractable severe and recurrent hypoglycemia, but that they can …