Mitochondrial dysfunction is a key pathway that links saturated fat intake to the development and progression of NAFLD
RCR Meex, EE Blaak - Molecular nutrition & food research, 2021 - Wiley Online Library
Non‐Alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and is
characterized by fat accumulation in the liver. Hypercaloric diets generally increase hepatic …
characterized by fat accumulation in the liver. Hypercaloric diets generally increase hepatic …
Action of thyroid hormones, T3 and T2, on hepatic fatty acids: differences in metabolic effects and molecular mechanisms
The thyroid hormones (THs) 3, 3′, 5, 5′-tetraiodo-l-thyronine (T4) and 3, 5, 3′-triiodo-l-
thyronine (T3) influence many metabolic pathways. The major physiological function of THs …
thyronine (T3) influence many metabolic pathways. The major physiological function of THs …
Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet
There is growing evidence that mitochondrial dysfunction, and more specifically fatty acid β-
oxidation impairment, is involved in the pathophysiology of non-alcoholic steatohepatitis …
oxidation impairment, is involved in the pathophysiology of non-alcoholic steatohepatitis …
The mitochondrial citrate carrier: metabolic role and regulation of its activity and expression
GV Gnoni, P Priore, MJH Geelen, L Siculella - IUBMB life, 2009 - Wiley Online Library
The citrate carrier (CiC), a nuclear‐encoded protein located in the mitochondrial inner
membrane, is a member of the mitochondrial carrier family. CiC plays an important role in …
membrane, is a member of the mitochondrial carrier family. CiC plays an important role in …
Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells
F Natali, L Siculella, S Salvati, GV Gnoni - Journal of Lipid Research, 2007 - ASBMB
Glial cells play a pivotal role in brain fatty acid metabolism and membrane biogenesis.
However, the potential regulation of lipogenesis and cholesterologenesis by fatty acids in …
However, the potential regulation of lipogenesis and cholesterologenesis by fatty acids in …
Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation
R Schoenfeld, A Wong, J Silva, M Li, A Itoh, M Horiuchi… - Mitochondrion, 2010 - Elsevier
Demyelination occurs in multiple inherited mitochondrial diseases. We studied which genes
were induced as a consequence of differentiation in rodent and human oligodendroglia …
were induced as a consequence of differentiation in rodent and human oligodendroglia …
[HTML][HTML] Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content
We investigated the effects of dietary trans fatty acids, PUFA, and SFA on body and liver fat
content, liver histology, and mRNA of enzymes involved in fatty acid metabolism. LDL …
content, liver histology, and mRNA of enzymes involved in fatty acid metabolism. LDL …
Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease
in western countries, being considered the hepatic manifestation of metabolic syndrome …
in western countries, being considered the hepatic manifestation of metabolic syndrome …
Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis
The accumulation of toxic hydrophobic bile acids in hepatocytes, observed during chronic
cholestasis, induces substantial modification in the redox state and in mitochondrial …
cholestasis, induces substantial modification in the redox state and in mitochondrial …
Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease
M Aoun, G Fouret, F Michel, B Bonafos… - Journal of bioenergetics …, 2012 - Springer
No data are reported on changes in mitochondrial membrane phospholipids in non-
alcoholic fatty liver disease. We determined the content of mitochondrial membrane …
alcoholic fatty liver disease. We determined the content of mitochondrial membrane …