Obesity and type 2 diabetes are becoming increasingly prevalent worldwide, and both are
associated with an increased incidence and mortality from many cancers. The metabolic …

New therapeutic approaches to counter the increasing prevalence of obesity and type 2
diabetes mellitus are in high demand. Deregulation of the phosphoinositide-3-kinase …

Insulin degludec (IDeg) is a new-generation basal insulin with an ultra-long duration of
action. To date, a large number of studies have been conducted to investigate the …

Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells
located in the endocrine pancreas in areas known as islets of Langerhans. The current …

To maintain copious insulin granule stores in the face of ongoing metabolic demand,
pancreatic beta cells must produce large quantities of proinsulin, the insulin precursor …

摘要背景各种因素都可以影响胰岛素类似物的药物代谢动力学与药效学特征.
当前这项研究的目的是在不同年龄, 糖尿病类型以及种族的受试者中每日1 …

The concept of a glucose-responsive insulin (GRI) has been a recent objective of diabetes
technology. The idea behind the GRI is to create a therapeutic that modulates its potency …

Abstract Purpose of Review Gestational diabetes (GDM) is associated with adverse
pregnancy and neonatal outcomes and increased maternal risk for subsequent type 2 …

Insulin is an important polypeptide hormone that regulates carbohydrate metabolism.
Abnormal levels of insulin are associated with diabetes mellitus that is characterized by …

Insulin production by the pancreas follows a basic pattern where basal levels of insulin are
secreted during fasting periods, with prandial increases in insulin associated with food …