Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC
develops in genetically susceptible individuals who are exposed to risk factors, especially in …

Use of germline genetic testing among patients with cancer is increasing because of (1) the
availability of multigene panel tests that include multiple cancer susceptibility genes in a …

These guidelines for the diagnosis and management of cholangiocarcinoma (CCA) were
commissioned by the British Society of Gastroenterology liver section. The guideline writing …

Simple Summary Hepatocellular carcinoma (HCC) is the fourth most common cause of
cancer-related deaths worldwide. HCC mostly results from liver cirrhosis and its genetic …

Characterization of the genomic landscape of biliary tract cancer (BTC) may lead to applying
genotype-matched therapy for patients with this disease. Evidence that comprehensive …

Background: Immunotherapy has been shown to improve outcomes for patients with cancer.
Biliary tract cancers are a group of lethal diseases, and immunotherapy is an exciting new …

Peri-hilar cholangiocarcinoma (pCCA) is chemorefractory and limited genomic analyses
have been undertaken in Western idiopathic disease. We undertook comprehensive …

Simple Summary The only curative treatment for intrahepatic cholangiocarcinoma (iCCA) is
surgical resection, and an early diagnosis is the most effective way to improve survival. In …

Introduction Chordoma is a rare slow-growing tumor that occurs along the length of the
spinal axis and arises from primitive notochordal remnants (Stepanek et al., Am J Med Genet …

PURPOSE Inherited cancer susceptibility is often not suspected in the absence of a
significant cancer family history. Pathogenic germline variants in pancreatic cancer are well …